Time Domain Optical Imaging
ART's new eXplore Optix MX2 is a high performance optical imaging system designed to characterize, quantify and visualize cellular and molecular events in living animals using fluorescent probes. Based on a proprietary time domain (TD) approach, eXplore Optix MX2 can be applied to further understand the mechanism of disease and evaluate the effects of therapy and disease progression.
In TD optical imaging, short pulses of light, driven by pulsed laser diodes, are sent to illuminate the specimen under study; where a fluorescent probe is excited and time-of-flight distribution is determined, enabling the uncoupling of depth and concentration. In addition, a fluorescence lifetime is derived - giving an important parameter in the measurement of tissue environment and allowing the distinction between different fluorescent sources.